Homosexuality as a Consequence of Epigenetically Canalized Sexual Development
نویسندگان
چکیده
منابع مشابه
Homosexuality as a consequence of epigenetically canalized sexual development.
Male and female homosexuality have substantial prevalence in humans. Pedigree and twin studies indicate that homosexuality has substantial heritability in both sexes, yet concordance between identical twins is low and molecular studies have failed to find associated DNA makers. This paradoxical pattern calls for an explanation. We use published data on fetal androgen signaling and gene regulati...
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We recently synthesized and reinterpreted published studies to advance an epigenetic model for the development of homosexuality (HS). The model is based on epigenetic marks laid down in response to the XX vs. XY karyotype in embryonic stem cells. These marks boost sensitivity to testosterone in XY fetuses and lower it in XX fetuses, thereby canalizing sexual development. Our model predicts that...
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ژورنال
عنوان ژورنال: The Quarterly Review of Biology
سال: 2012
ISSN: 0033-5770,1539-7718
DOI: 10.1086/668167